Balle V H, Pedersen U, Engby B
Acta Otolaryngol. 1982 Jul-Aug;94(1-2):169-73. doi: 10.3109/00016488209128901.
The investigation of a recently synthesized non-halogenated steroid with a high local anti-inflammatory effect and low systemic glucocorticoid effect, on 36 patients with perennial rhinitis was carried out using a double-blind, cross-over technique, where the patients were treated with an aerosol spray containing a concentration corresponding to 200 micrograms/day and 400 micrograms/day of the active compound Budesonide, as well as placebo. There was a significantly better effect from the active compound than from placebo. A dosage-dependent effect was demonstrated for the symptoms nasal blockage and nasal discharge, while this was not so for sneezing bouts. No effect was observed on the function of the suprarenal glands. Local side effects were few and of no importance.
对一种最近合成的具有高局部抗炎作用和低全身糖皮质激素作用的非卤化类固醇进行了研究，采用双盲交叉技术对36例常年性鼻炎患者进行治疗，患者分别接受含有相当于活性化合物布地奈德200微克/天和400微克/天浓度的气雾剂喷雾治疗，以及安慰剂治疗。活性化合物的效果明显优于安慰剂。对于鼻塞和流鼻涕症状显示出剂量依赖性效应，而打喷嚏发作则不然。未观察到对肾上腺功能的影响。局部副作用很少且无关紧要。
