Prentice R L, Szatrowski T P, Fujikura T, Kato H, Mason M W, Hamilton H H
Am J Epidemiol. 1982 Sep;116(3):496-509. doi: 10.1093/oxfordjournals.aje.a113434.
Coronary heart disease incidence during 1958-1974, in a cohort of Hiroshima and Nagasaki residents, was found to relate significantly (p = 0.01) to total leukocyte count, taken an average of two years earlier. Relative risks, as a function of leukocyte count, did not appear to depend on sex or cigarette smoking status, but may be larger for subjects less than 65 years of age than for older persons. This study examines, for the first time, differential leukocyte counts and percentages in relation to coronary heart disease incidence. Both neutrophil count and eosinophil count significantly relate to coronary heart disease incidence, while there is also a suggestion for a relationship with monocyte count. A possible immunopathologic basis for such associations is mentioned. It will be important for other studies to confirm these relationships, however, as the present data do not allow one to clearly show the relative risk, at a specified total leukocyte count, to depend on the differential leukocyte fractions. Available data also leave uncertainty concerning the "independence" of leukocyte counts in the specification of coronary heart disease risk, relative to such known risk factors as cigarette smoking habits and serum cholesterol levels.
1958年至1974年期间，在广岛和长崎居民队列中发现，冠心病发病率与平均两年前的白细胞总数显著相关（p = 0.01）。作为白细胞计数函数的相对风险，似乎不取决于性别或吸烟状况，但65岁以下的受试者可能比老年人的相对风险更大。本研究首次考察了与冠心病发病率相关的白细胞分类计数和百分比。中性粒细胞计数和嗜酸性粒细胞计数均与冠心病发病率显著相关，同时也提示与单核细胞计数存在关联。文中提到了此类关联可能的免疫病理基础。然而，其他研究对这些关系进行确认将很重要，因为目前的数据无法明确显示在特定白细胞总数下，相对风险取决于白细胞分类比例。现有数据也使得白细胞计数在确定冠心病风险时相对于吸烟习惯和血清胆固醇水平等已知风险因素的“独立性”存在不确定性。
