Olivares R, Ducimetière P, Claude J R
Cardiovascular Epidemiology Unit, INSERM U258, Paris, France.
Am J Epidemiol. 1993 Jan 1;137(1):49-53. doi: 10.1093/oxfordjournals.aje.a116601.
Previous studies have reported total leukocyte count to be a risk factor for coronary heart disease. The pattern of association between each class of leukocytes and the onset of the disease was investigated in the Paris Prospective Study II. The study population consisted of 3,779 male French employees aged 29-52 years working in the Paris area and recruited between 1980 and 1985 (end of follow-up: June 1989). A high monocyte count was strongly associated with the risk of coronary heart disease after adjustment for tobacco use and the other classical risk factors for the disease. The monocyte-macrophage is known to play an important part in the development of atherosclerosis. A high monocyte count seems to predict the premature occurrence of a coronary event in middle-aged men.
先前的研究报告称，白细胞总数是冠心病的一个风险因素。在巴黎前瞻性研究II中，研究了各类白细胞与该疾病发病之间的关联模式。研究人群包括1980年至1985年（随访结束时间：1989年6月）在巴黎地区工作、年龄在29至52岁之间的3779名法国男性雇员。在对吸烟情况和该疾病的其他经典风险因素进行调整后，单核细胞计数高与冠心病风险密切相关。已知单核细胞 - 巨噬细胞在动脉粥样硬化的发展中起重要作用。单核细胞计数高似乎预示着中年男性会过早发生冠心病事件。
