Lim M, Linton R A, Band D M
Anesthesiology. 1982 Oct;57(4):272-8. doi: 10.1097/00000542-198210000-00004.
Ion-selective electrode catheters were used for continuous monitoring of epinephrine-induced changes in plasma potassium in different parts of the circulation of anesthetized greyhounds. Bolus injections and continuous infusions of epinephrine produced dose-related changes consisting of an initial transient increase followed by a decrease to levels below control. The latter part of the response was relatively short-lived in the case of bolus injections, but when the epinephrine was administered by continuous infusion, a progressive fall was maintained for the duration of the infusion. During the period when potassium levels were undergoing an acute change, marked differences were seen between concentrations in different parts of the circulation. Further studies are needed to delineate the incidence and extent of similar changes in humans, and their significance in producing dangerous dysrhythmias.
离子选择性电极导管用于连续监测肾上腺素诱导的麻醉灵缇犬不同循环部位血浆钾的变化。静脉推注和持续输注肾上腺素会产生剂量相关的变化，包括最初的短暂升高，随后降至低于对照水平。在静脉推注的情况下，反应的后一部分持续时间相对较短，但当通过持续输注给予肾上腺素时，在输注期间会维持逐渐下降。在钾水平发生急性变化的期间，循环不同部位的浓度存在明显差异。需要进一步研究来描述人类中类似变化的发生率和程度，以及它们在产生危险心律失常方面的意义。
