Dose-response study of oral fenoterol in asthmatic children.

To assess the dose of oral fenoterol, a beta 2-receptor stimulant, which provided optimal bronchodilation with minimal side effects, we studied 12 children using a double-blind crossover comparison of three dose levels, 2.5, 5 and 7.5 mg, and a placebo. ventilatory function, pulse rate, blood pressure and clinical examination were compared over a 3-hour period. Administration of fenoterol resulted in bronchodilation; a maximal effect was seen at 60--90 min lasting over the period of the study. 7.5 mg of fenoterol produced the maximal bronchodilation, but it was not significantly different from 5 mg. Side effects were minimal and no significant drug-response relationship was noted for blood pressure and pulse rate. 5 mg of fenoterol provided optimal bronchodilation with minimal side effects.