Tamura S, Enjoji M
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Acta Pathol Jpn. 1988 Dec;38(12):1537-46. doi: 10.1111/j.1440-1827.1988.tb02293.x.
We studied a series of 585 patients with non-invasive or invasive ductal carcinoma in an attempt to assess the significance of elastosis. Elastosis in the neoplasm was recognized in 60% of the 549 patients with invasive ductal carcinoma. The grade of elastosis was correlated with both the histologic grade of differentiation and the 5-year survival rate. The incidence of elastosis, however, was 17% in the 36 patients with non-invasive ductal carcinoma and 38% in the 21 with invasive ductal carcinoma with a predominant intraductal component. The increased elastic tissue may therefore be influenced by the stromal infiltration of cancer cells. Mastectomy specimens from another series of 100 patients with mammary carcinoma were examined with regard to the volume of elastic tissue. Increased periductal elastic fibers were also identified in the non-neoplastic tissue, but the volume density was far less than in the neoplasm. A significant correlation was found between the increased amount of periductal elastic fibers in the non-neoplastic tissue, periductal elastosis of the neoplasm and an increase in parity. We propose that cancer cells in mammary carcinoma exert an inductive effect on mesenchymal cells for the synthesis of elastic material, under the basic condition of an increased amount of elastic fibers with an increase in parity.
我们研究了585例非浸润性或浸润性导管癌患者，试图评估弹性组织变性的意义。在549例浸润性导管癌患者中，60%的肿瘤存在弹性组织变性。弹性组织变性的分级与组织学分化程度和5年生存率均相关。然而，在36例非浸润性导管癌患者中，弹性组织变性的发生率为17%，在21例以导管内成分为主的浸润性导管癌患者中为38%。因此，弹性组织增加可能受癌细胞间质浸润的影响。对另一组100例乳腺癌患者的乳房切除术标本进行了弹性组织体积检查。在非肿瘤组织中也发现导管周围弹性纤维增加，但体积密度远低于肿瘤组织。在非肿瘤组织中导管周围弹性纤维数量增加、肿瘤的导管周围弹性组织变性与产次增加之间存在显著相关性。我们提出，在弹性纤维数量随着产次增加而增多的基础条件下，乳腺癌中的癌细胞对间充质细胞合成弹性物质发挥诱导作用。
