Tulusan A H, Egger H, Schneider M L, Willgeroth F
Arch Gynecol. 1982;231(3):219-26. doi: 10.1007/BF02110121.
We studied 52 patients with lobular carcinoma in situ (LCIS) of the breast, tissue being available from both breasts in 46 patients. Detailed histological examination of the tissue was combined with specimen radiography. By this technique, six invasive cancers were detected within 2 years of the primary diagnosis. five of these six carcinomas were clinically occult and were not suspected at specimen radiography. Three other invasive cancers were discovered 4 years, 7 years, and 10 years after diagnosing LCIS. The extent of the LCIS in the primary biopsy was the only feature which gave a guide to the possible presence and location of an occult invasive lesion.
我们研究了52例乳腺小叶原位癌（LCIS）患者，其中46例患者双侧乳房均有组织样本。对组织进行了详细的组织学检查，并结合了标本射线照相术。通过这种技术，在初次诊断后的2年内检测到6例浸润性癌。这6例癌中有5例在临床上隐匿，在标本射线照相时未被怀疑。在诊断LCIS后的4年、7年和10年又发现了另外3例浸润性癌。初次活检时LCIS的范围是唯一能提示隐匿性浸润性病变可能存在及位置的特征。
