Gershon E S, Hamovit J, Guroff J J, Dibble E, Leckman J F, Sceery W, Targum S D, Nurnberger J I, Goldin L R, Bunney W E
Arch Gen Psychiatry. 1982 Oct;39(10):1157-67. doi: 10.1001/archpsyc.1982.04290100031006.
In a family study of 1,254 adult relatives of patients and controls, lifetime prevalences of major affective disorder (including schizoaffective) were 37%, 24%, 25%, 20% and 7% in relatives of probands with schizoaffective, bipolar I, bipolar II, and unipolar disease, and normal controls. These data were compatible with the different affective disorders representing thresholds on a continuum of underlying multifactorial vulnerability. In this model, schizoaffective illness represents greatest vulnerability, followed by bipolar I and bipolar II, then unipolar illnesses. Alcoholism, drug abuse, and sociopathy were not more frequent in relatives of patients v relatives of controls. Sex-related transmission of morbid risk was not present. Morbid risk was 74% to offspring of two III parents, and 27% to offspring of one III parent. Nationality and age at time of interview seem to be nongenetic factors that affect frequency of diagnosis.
在一项针对1254名患者及对照的成年亲属的家族研究中，精神分裂情感障碍患者、I型双相情感障碍患者、II型双相情感障碍患者、单相情感障碍患者以及正常对照的亲属中，严重情感障碍（包括精神分裂情感障碍）的终生患病率分别为37%、24%、25%、20%和7%。这些数据与不同的情感障碍代表潜在多因素易感性连续体上的阈值这一观点相符。在该模型中，精神分裂情感障碍代表最大的易感性，其次是I型双相情感障碍和II型双相情感障碍，然后是单相情感障碍。患者亲属中酒精中毒、药物滥用和反社会人格障碍的发生率并不高于对照亲属。不存在与性别相关的发病风险传递。两个III级亲属的后代发病风险为74%，一个III级亲属的后代发病风险为27%。国籍和访谈时的年龄似乎是影响诊断频率的非遗传因素。
