Petrov S A, Vasil'ev A V
Arkh Patol. 1982;44(7):52-8.
A comparative study of neuroleukemia in children with acute leukemia and in mice with experimental leukemia was carried out. Spontaneous leukemia in AKR mice and transplantation leukemia (LIO-I, La, P388, L-5178Y) were shown to be adequate models for investigations on the pathogenesis of neuroleukemia. The initial morphological manifestations of neuroleukemia consisted in infiltration of dura mater of the brain and epidural space, particularly of the lumbar region of the spine. The leukemic cell infiltrates originating from the bone marrow spread along the walls of vascular anastomoses between the venous system of the skull and vertebrae on the one hand, and dura mater of the brain and epidural space of the spinal cord, on the other.
对急性白血病患儿和实验性白血病小鼠的神经白血病进行了一项比较研究。结果表明，AKR小鼠的自发性白血病和移植性白血病（LIO-I、La、P388、L-5178Y）是研究神经白血病发病机制的合适模型。神经白血病的初始形态学表现为脑硬脑膜和硬膜外间隙，特别是脊柱腰段的浸润。源自骨髓的白血病细胞浸润一方面沿着颅骨和椎骨静脉系统之间的血管吻合壁扩散，另一方面沿着脑硬脑膜和脊髓硬膜外间隙扩散。
