Svartaas T M, Smeby L C, Jørstad S, Naess T B, Widerøe T E, Holtz M
Artif Organs. 1982 May;6(2):136-44. doi: 10.1111/j.1525-1594.1982.tb04075.x.
Transport properties of different artificial kidney membranes have been studied employing substances with molecular weights ranging from 60 daltons (urea) to 62,000 daltons (dextran). The results from these studies were used to select filters for the SElective DUal Filtration ARtificial Kidney, SEDUFARK. Selection criteria for filters to be used in long-term clinical trials with SEDUFARK were based on biological tests showing toxicity of large molecular weight substances in uremic blood plasma and clinical advantages of returning middle molecular weight substances to the patient. The filters selected were used for evaluation in vitro of the complete SEDUFARK system. The results confirmed a theoretical analysis of this system, demonstrating that selective removal of substances within given molecular weight ranges from uremic blood plasma is feasible with a combination of commercial filters. The efficiency of the system, however, is limited due to the "cut-off" characteristics and hydraulic permeabilities of membrane types currently available.
已使用分子量范围从60道尔顿（尿素）到62,000道尔顿（右旋糖酐）的物质研究了不同人工肾膜的传输特性。这些研究结果被用于为选择性双重过滤人工肾（SEDUFARK）选择滤器。用于SEDUFARK长期临床试验的滤器选择标准基于生物学测试，该测试表明尿毒症血浆中大分子物质具有毒性，以及将中分子物质回输给患者的临床优势。所选滤器用于对完整的SEDUFARK系统进行体外评估。结果证实了对该系统的理论分析，表明通过组合商业滤器从尿毒症血浆中选择性去除给定分子量范围内的物质是可行的。然而，由于目前可用膜类型的“截留”特性和水力渗透性，该系统的效率受到限制。
