Smeby L C, Jørstad S, Wilderøe T E
Clin Nephrol. 1980 Mar;13(3):125-32.
A new system for removal of uremic toxins is described, The system is based on selective removal of small (urea, creatinine) and large uremic toxins through a multimembrane filter/dialyzer unit. Theoretical calculations show that the system is capable of removing the desired range of molecules from uremic plasma, while retaining a large portion of non-toxic elements in the blood. The SElective DUal Filtration ARtificial Kidney can be optimized and assembled into a single compact unit, which is simple to use and requires minimal monitoring equipment. Preliminary clinical trials indicate that SEDUFARK is a feasible system for treatment of uremic patients.
描述了一种用于去除尿毒症毒素的新系统。该系统基于通过多膜过滤器/透析器单元选择性去除小分子（尿素、肌酐）和大分子尿毒症毒素。理论计算表明，该系统能够从尿毒症血浆中去除所需范围的分子，同时在血液中保留大部分无毒成分。选择性双重过滤人工肾可以进行优化并组装成一个紧凑的单一单元，使用简单，所需监测设备最少。初步临床试验表明，选择性双重过滤人工肾是治疗尿毒症患者的可行系统。
