McBride W G, Vardy P H, French J
Aust J Biol Sci. 1982;35(2):173-8. doi: 10.1071/bi9820173.
When 100 or 200 microgram of scopolamine hydrobromide were injected into hen eggs after they had been incubated for 96 h the major malformations of the embryo found were gastroschisis, exencephaly, reduction deformities of the limbs, microphthalmia and buphthalmia when the eggs were opened on the 12th day of incubation. Eight foetuses of one of eight New Zealand white rabbit does given scopolamine hydrobromide at the rate of 473 microgram/kg in their drinking water from the 10th to the 14th day of gestation showed malformations consisting of microphthalmia, buphthalmia, exencephaly and hydrocephaly. A second doe which similarly received 520 microgram/kg of the hydrobromide had four malformed foetuses showing microphthalmia and had two foetuses which were resorbed. However, there were no malformations in foetuses of eight does given bolus doses of scopolamine hydrobromide ranging from 37 to 184 microgram/kg by intramuscular injection every 12 h from the 10th to the 14th day of gestation. Results indicate interference by the drug with the function of the cholinergic nerves on the development of the chick and rabbit embryo.
在鸡蛋孵化96小时后，向其中注射100或200微克氢溴酸东莨菪碱，当在孵化第12天打开鸡蛋时，发现胚胎的主要畸形有腹裂、无脑儿、肢体发育不全畸形、小眼畸形和牛眼畸形。8只新西兰白兔母兔中的1只，在妊娠第10天至第14天期间，以473微克/千克的剂量通过饮水给予氢溴酸东莨菪碱，其8只胎儿中有8只出现畸形，包括小眼畸形、牛眼畸形、无脑儿和脑积水。另一只母兔同样接受了520微克/千克的氢溴酸东莨菪碱，有4只畸形胎儿表现为小眼畸形，2只胎儿被吸收。然而，在妊娠第10天至第14天期间，每12小时给8只母兔肌肉注射大剂量氢溴酸东莨菪碱，剂量范围为37至184微克/千克，其胎儿未出现畸形。结果表明，该药物干扰了胆碱能神经对鸡和兔胚胎发育的功能。
