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用溶壁微球菌免疫的家兔中抗牛血清白蛋白反应的限制。

Restriction of the anti-bovine serum albumin response in rabbits immunized with Micrococcus lysodeikticus.

作者信息

De Baetselier P, Hamers-Casterman C, Van der Loo W, Hamers R

出版信息

Immunology. 1977 Sep;33(3):275-84.

PMID:71263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445633/
Abstract

Rabbits capable of producing antibodies of restricted heterogeneity in response to Micrococcus lysodeikticus are equally capable of producing antibodies of restricted heterogeneity to bovine serum albumin. These antibodies are produced when animals are simultaneously injected with micrococcus and BSA and their specificity is restricted to a small number of epitopes. These results suggest that micrococcal vaccines can induce the restriction of heterogeneity in antibodies raised against totally unrelated antigens.

摘要

能够针对溶壁微球菌产生异质性受限抗体的兔子，同样能够针对牛血清白蛋白产生异质性受限的抗体。当动物同时注射微球菌和牛血清白蛋白时，就会产生这些抗体，并且它们的特异性仅限于少数表位。这些结果表明，微球菌疫苗可以诱导针对完全不相关抗原产生的抗体的异质性受限。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/b2651e711a59/immunology00284-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/b1c3188f9e38/immunology00284-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/fc7eefbdd990/immunology00284-0008-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/240d9c6ccfb1/immunology00284-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/05ab05b67803/immunology00284-0009-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/72f74e1ae957/immunology00284-0009-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/b2651e711a59/immunology00284-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/b1c3188f9e38/immunology00284-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/fc7eefbdd990/immunology00284-0008-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/240d9c6ccfb1/immunology00284-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/05ab05b67803/immunology00284-0009-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/72f74e1ae957/immunology00284-0009-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd3/1445633/b2651e711a59/immunology00284-0010-a.jpg

相似文献

1
Restriction of the anti-bovine serum albumin response in rabbits immunized with Micrococcus lysodeikticus.用溶壁微球菌免疫的家兔中抗牛血清白蛋白反应的限制。
Immunology. 1977 Sep;33(3):275-84.
2
[Evolution of the immune response against Micrococcus lysodeikticus].[针对溶壁微球菌的免疫反应的演变]
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):345-9.
3
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Z Immunitatsforsch Exp Klin Immunol. 1975 Jul;149(2-4):193-200.
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Serum antibody-binding antibodies produced during a primary antibody response.在初次抗体应答过程中产生的血清抗体结合抗体。
J Immunol. 1981 Jun;126(6):2136-8.
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Heterogeneity in combining site specificity of anti-hapten antibodies produced in response to a panosyl-azoprotein conjugate.针对全糖基偶氮蛋白缀合物产生的抗半抗原抗体结合位点特异性的异质性。
Eur J Immunol. 1973 Nov;3(11):693-8. doi: 10.1002/eji.1830031108.
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Systemic antibody responses of different species following ingestion of soluble protein antigens.摄入可溶性蛋白质抗原后不同物种的全身抗体反应。
Dev Comp Immunol. 1982 Fall;6(4):737-46.
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Immunochemistry of Salmonella O-antigens: specificity of rabbit antibodies against the O-antigen 2 determinant elicited by whole bacteria and 3-O-alpha-paratopyranosyl-D-mannopyranosyl conjugated to bovine serum albumin.沙门氏菌O抗原的免疫化学：全菌及与牛血清白蛋白偶联的3-O-α-副吡喃甘露糖基-D-甘露吡喃糖基引发的兔抗O抗原2决定簇抗体的特异性
Int Arch Allergy Appl Immunol. 1980;61(1):55-64.
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The mechanism of breakdown of immune tolerance to a protein antigen in rabbits.兔对蛋白质抗原免疫耐受的破坏机制。
Immunology. 1971 May;20(5):719-26.
9
Immune responses to complex protein antigens I. MHC control of immune responses to bovine albumin.对复杂蛋白质抗原的免疫反应I. 主要组织相容性复合体对牛血清白蛋白免疫反应的控制
J Immunol. 1982 Oct;129(4):1553-8.
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Specific removal of bovine serum albumin (BSA) antibodies in vivo by extracorporeal circulation over BSA immobilized on nylon microcapsules.通过体外循环在固定于尼龙微胶囊上的牛血清白蛋白（BSA）上进行体内特异性去除牛血清白蛋白（BSA）抗体。
J Immunol. 1976 May;116(5):1337-41.

本文引用的文献

1
Influence of genetic factors on the magnitude and the heterogeneity of the immune response in the rabbit.遗传因素对家兔免疫反应强度及异质性的影响。
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Streptococcal group-specific antibodies: occurrence of a restricted population following secondary immunization.链球菌属特异性抗体：二次免疫后出现受限群体
Proc Natl Acad Sci U S A. 1968 May;60(1):134-9. doi: 10.1073/pnas.60.1.134.
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Lectins: cell-agglutinating and sugar-specific proteins.凝集素：细胞凝集性且具有糖特异性的蛋白质。
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Relationships between relative binding affinity and electrophoretic behavior of rabbit antibodies to streptococcal carbohydrates.兔抗链球菌碳水化合物抗体的相对结合亲和力与电泳行为之间的关系。
J Exp Med. 1971 Mar 1;133(3):424-41. doi: 10.1084/jem.133.3.424.
5
The immunochemistry of peptidoglycan. Separation and characterization of antibodies to the glycan and to the peptide subunit.肽聚糖的免疫化学。聚糖抗体和肽亚基抗体的分离与特性鉴定。
Eur J Biochem. 1971 Apr 30;19(4):471-8. doi: 10.1111/j.1432-1033.1971.tb01337.x.
6
Selective enzyme purification by affinity chromatography.通过亲和色谱法进行选择性酶纯化。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):636-43. doi: 10.1073/pnas.61.2.636.
7
Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
Immunochemistry. 1965 Sep;2(3):235-54. doi: 10.1016/0019-2791(65)90004-2.
8
A rabbit family of restricted high responders to the streptococcal group A-variant polysaccharide. Selective breeding narrows the isoelectric focusing spectra of dominant clones.对A组链球菌变异多糖反应受限的高反应性家兔。选择性育种可使优势克隆的等电聚焦谱变窄。
J Exp Med. 1973 Sep 1;138(3):645-58. doi: 10.1084/jem.138.3.645.
9
Active suppression of immunoglobulin allotype synthesis. II. Transfer of suppressing factor with spleen cells.免疫球蛋白同种异型合成的主动抑制。II. 抑制因子与脾细胞的转移。
J Exp Med. 1972 May 1;135(5):1163-76. doi: 10.1084/jem.135.5.1163.
10
Genetically controlled idiotype expression in inbred mice.近交系小鼠中基因控制的独特型表达
Ann Immunol (Paris). 1974 Jan;125C(1-2):359-61.