吲哚美辛和萘普生对血浆泼尼松龙水平的影响。
Alteration of plasma prednisolone levels by indomethacin and naproxen.
作者信息
Rae S A, Williams I A, English J, Baylis E M
出版信息
Br J Clin Pharmacol. 1982 Sep;14(3):459-61. doi: 10.1111/j.1365-2125.1982.tb02010.x.
Abstract
Eleven patients with stable rheumatoid disease (RD) who were receiving regular corticosteroid therapy (CS) were investigated to discover the effect on plasma prednisolone levels of additional therapy with the non-steroidal anti-inflammatory (NSAI) drugs, indomethacin and naproxen. There was a highly significant (P less than 0.001) increase in free prednisolone levels after concurrent therapy with either indomethacin or naproxen for 2 weeks. Total prednisolone levels were unchanged. These results could provide an explanation for clinical reports that these two NSAI drugs possess a steroid-sparing effect.
摘要
对11名正在接受常规皮质类固醇治疗（CS）的稳定型类风湿病（RD）患者进行了研究，以探讨非甾体抗炎药（NSAI）吲哚美辛和萘普生的附加治疗对血浆泼尼松龙水平的影响。在同时使用吲哚美辛或萘普生治疗2周后，游离泼尼松龙水平有极显著升高（P<0.001）。泼尼松龙总水平未变。这些结果可以解释关于这两种NSAI药物具有激素节省效应的临床报告。
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Gut. 1980 Jan;21(1):49-51. doi: 10.1136/gut.21.1.49.
2
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JAMA. 1966 Mar 28;195(13):1102-6.
3
Displacement of one drug by another from carrier or receptor sites.一种药物被另一种药物从载体或受体部位置换出来。
Proc R Soc Med. 1965 Nov;58(11 Part 2):946-55. doi: 10.1177/003591576505811P202.
4
Drug therapy. Serum drug concentrations as therapeutic guides.药物治疗。作为治疗指导的血清药物浓度。
N Engl J Med. 1972 Aug 3;287(5):227-31. doi: 10.1056/NEJM197208032870505.
5
Therapeutic value of indomethacin. (A review and clinical study).消炎痛的治疗价值。（综述与临床研究）
Curr Ther Res Clin Exp. 1966 Apr;8(4):179-86.
6
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J Pharm Pharmacol. 1969 Jul;21(7):451-9. doi: 10.1111/j.2042-7158.1969.tb08286.x.
7
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8
[Steroid saving effect of naproxen].
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