赖氨酸加压素和催产素对中枢心血管控制的影响。
Effects of lysine-vasopressin and oxytocin on central cardiovascular control.
作者信息
Tran L D, Montastruc J L, Montastruc P
出版信息
Br J Pharmacol. 1982 Sep;77(1):69-73. doi: 10.1111/j.1476-5381.1982.tb09270.x.
1 The cardiovascular effects of intravenous and intracisternal administration of neurohypophysial peptides were compared in dogs anaesthetized with chloralose. 2 Intravenous lysine-vasopressin (0.1 to 100 mu/kg) induced a dose-dependent increase in blood pressure and a decrease in heart rate. In contrast, intracisternal lysine-vasopressin (0.01 to 10 mu/kg induced a dose-related decrease in blood pressure and did not change heart rate. 3 Intracisternal oxytocin (1 and 10 mu/kg) increased blood pressure and did not change heart rate, whereas the same doses injected intravenously were inactive. 4 Pretreatment with guanethidine (15 mg/kg i.v. 24 h beforehand) abolished the hypotensive responses to intracisternal vasopressin but not the pressor action of intravenous vasopressin. 5 The pressor responses to central injections of oxytocin were not modified by guanethidine. 6 Hypotension elicited by intracisternal vasopressin was probably due to a decrease in sympathetic tone whereas the hypertension induced by intracisternal oxytocin was independent of variations in sympathetic tone.
- 比较了在水合氯醛麻醉的犬中静脉内和脑池内给予神经垂体肽的心血管效应。2. 静脉内给予赖氨酸加压素（0.1至100 μ/kg）可引起血压剂量依赖性升高和心率降低。相反，脑池内给予赖氨酸加压素（0.01至10 μ/kg）可引起血压剂量相关降低，且心率无变化。3. 脑池内给予催产素（1和10 μ/kg）可升高血压且心率无变化，而静脉内注射相同剂量则无活性。4. 预先用胍乙啶（15 mg/kg静脉内注射，提前24小时）处理可消除对脑池内加压素的降压反应，但不影响静脉内加压素的升压作用。5. 胍乙啶不改变对脑池内注射催产素的升压反应。6. 脑池内加压素引起的低血压可能是由于交感神经张力降低，而脑池内催产素引起的高血压与交感神经张力变化无关。
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