梅毒血清和免疫复合物对自然杀伤细胞活性的抑制作用。
Depression of natural killer cell activity by syphilitic serum and immune complexes.
作者信息
Jensen J R, Jørgensen A S, Thestrup-Pedersen K
出版信息
Br J Vener Dis. 1982 Oct;58(5):298-301. doi: 10.1136/sti.58.5.298.
Abstract
Consecutive serum samples were obtained from patients with syphilis before and on three occasions after treatment. The sera contained immunosuppresive factors associated with the immunoglobulin fraction, which could depress the natural killer cell activity of healthy controls. There was no evidence that allogeneic or lymphocytotoxic antibodies played a role in immuno-suppression, which could be reproduced with both soluble and insoluble antigen-IgG-antibody complexes.
摘要
从梅毒患者治疗前及治疗后三个不同时间点采集连续的血清样本。这些血清中含有与免疫球蛋白部分相关的免疫抑制因子，该因子可抑制健康对照者的自然杀伤细胞活性。没有证据表明同种异体抗体或淋巴细胞毒性抗体在免疫抑制中起作用，可溶性和不溶性抗原 - IgG - 抗体复合物均可导致免疫抑制。
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