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相似文献

1
In vitro cell response of Treponema pallidum-infected rabbits. II. Inhibition of lymphocyte response to phytohaemagglutinin by serum of T. pallidum-infected rabbits.梅毒螺旋体感染兔的体外细胞反应。II. 梅毒螺旋体感染兔血清对淋巴细胞对植物血凝素反应的抑制作用。
Clin Exp Immunol. 1977 Sep;29(3):487-95.
2
In vitro cell response of Treponema pallidum-infected rabbits. I. Lymphocyte transformation.梅毒螺旋体感染兔的体外细胞反应。I. 淋巴细胞转化
Clin Exp Immunol. 1977 Sep;29(3):480-6.
3
Effect of route of infection with Treponema pallidum. In vitro cellular response to treponemal antigens.梅毒螺旋体感染途径的影响。对梅毒螺旋体抗原的体外细胞反应。
Arch Pathol Lab Med. 1982 Sep;106(9):436-9.
4
In vitro cell response of Treponema pallidum-infected rabbits. III. Impairment in production of lymphocyte mitogenic factor.梅毒螺旋体感染兔的体外细胞反应。III. 淋巴细胞促有丝分裂因子产生的损害。
Clin Exp Immunol. 1977 Sep;29(3):496-500.
5
Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens.早期实验性梅毒中淋巴细胞反应性的特征。I. 对有丝分裂原和梅毒螺旋体抗原的体外反应
J Immunol. 1980 Jan;124(1):454-60.
6
Cell-mediated immunity in Treponema pallidum infected rabbits: in vitro response of splenic and lymph node lymphocytes to mitogens and specific antigens.梅毒螺旋体感染兔的细胞介导免疫：脾和淋巴结淋巴细胞对有丝分裂原和特异性抗原的体外反应
Clin Exp Immunol. 1980 Jan;39(1):38-43.
7
Syphilis superinfection activates expression of human immunodeficiency virus I in latently infected rabbits.梅毒重复感染激活潜伏感染兔体内人类免疫缺陷病毒I的表达。
Am J Pathol. 1991 May;138(5):1149-64.
8
Humoral immune response in experimental syphilis to polypeptides of Treponema pallidum.实验性梅毒中针对梅毒螺旋体多肽的体液免疫反应。
J Immunol. 1983 Oct;131(4):1973-7.
9
Host response to treponema pallidum infection. II. Rabbit leukocyte migration inhibition in the presence of homologous organ extracts.宿主对梅毒螺旋体感染的反应。II. 同源器官提取物存在下兔白细胞迁移抑制。
Int Arch Allergy Appl Immunol. 1977;55(1-6):481-6.
10
Administration of antithymocyte serum to syphilitic rabbits inhibits development of resistance to reinfection with Treponema pallidum.给患梅毒的兔子注射抗胸腺细胞血清会抑制其对梅毒螺旋体再次感染产生抵抗力的发展。
Arch Immunol Ther Exp (Warsz). 1984;32(1):37-42.

引用本文的文献

1
Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis.梅毒螺旋体的抗原变异：在实验性梅毒过程中，TprK 序列的多样性因免疫压力而积累。
J Immunol. 2010 Apr 1;184(7):3822-9. doi: 10.4049/jimmunol.0902788. Epub 2010 Feb 26.
2
Sequential changes in susceptibility to Treponema pallidum of rabbits previously infected with Treponema paraluis-cuniculi.先前感染了兔梅毒螺旋体的兔子对梅毒螺旋体易感性的序贯变化。
Br J Vener Dis. 1981 Feb;57(1):11-4. doi: 10.1136/sti.57.1.11.
3
Depression of natural killer cell activity by syphilitic serum and immune complexes.梅毒血清和免疫复合物对自然杀伤细胞活性的抑制作用。
Br J Vener Dis. 1982 Oct;58(5):298-301. doi: 10.1136/sti.58.5.298.
4
Accelerated lesion development in experimental syphilis.实验性梅毒中病变的加速发展。
Infect Immun. 1981 Nov;34(2):478-82. doi: 10.1128/iai.34.2.478-482.1981.
5
A histopathologic and immunologic study of the course of syphilis in the experimentally infected rabbit. Demonstration of long-lasting cellular immunity.对实验感染兔梅毒病程的组织病理学和免疫学研究。持久细胞免疫的证明。
Am J Pathol. 1980 Nov;101(2):387-414.
6
Molecular characterization of receptor binding proteins and immunogens of virulent Treponema pallidum.梅毒螺旋体强毒株受体结合蛋白和免疫原的分子特征分析
J Exp Med. 1980 Mar 1;151(3):573-86. doi: 10.1084/jem.151.3.573.
7
T lymphoid cells in primary syphilis. Quantitative studies.一期梅毒中的T淋巴细胞。定量研究。
Br J Vener Dis. 1980 Apr;56(2):74-6. doi: 10.1136/sti.56.2.74.
8
Serum regulation of in vitro lymphocyte responses in early experimental syphilis.早期实验性梅毒中血清对体外淋巴细胞反应的调节作用
Infect Immun. 1982 Aug;37(2):568-78. doi: 10.1128/iai.37.2.568-578.1982.
9
Detection of circulating immune complexes in the sera of rabbits with experimental syphilis: possible role in immunoregulation.实验性梅毒兔血清中循环免疫复合物的检测：在免疫调节中的可能作用。
Infect Immun. 1980 Aug;29(2):575-82. doi: 10.1128/iai.29.2.575-582.1980.
10
An immunosuppressive factor in the serum of baboons (Papio anubis) infected with Schistosoma mansoni.感染曼氏血吸虫的狒狒（埃及狒狒）血清中的一种免疫抑制因子。
Immunology. 1980 Apr;39(4):589-98.

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Reactivity of human lymphocytes to autologous and homologous serum.
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2
Cytotoxins in disease. Autocytotoxins in lupus.疾病中的细胞毒素。狼疮中的自身细胞毒素。
N Engl J Med. 1970 Oct 1;283(14):724-8. doi: 10.1056/NEJM197010012831403.
3
Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response.麻风病免疫机制研究。3. 细胞和体液因素在体外免疫反应受损中的作用。
J Immunol. 1971 Apr;106(4):888-99.
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Metal cation requirements for phytohemagglutinin-induced transformation of human peripheral blood lymphocytes.植物血凝素诱导人外周血淋巴细胞转化所需的金属阳离子
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In vitro lymphocyte response to Treponema refringens im human syphilis.人梅毒中对致密螺旋体的体外淋巴细胞反应。
Infect Immun. 1974 Apr;9(4):654-7. doi: 10.1128/iai.9.4.654-657.1974.
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Purification and properties of a lymphocyte inhibition factor from human serum.人血清中淋巴细胞抑制因子的纯化及性质
Clin Exp Immunol. 1973 Oct;15(2):169-79.
7
Serum factors affecting the incorporation of (3H)thymidine by lymphocytes stimulated by antigen. 3. Evidence for a role of complement from studies with specific complement inhibitors.影响抗原刺激淋巴细胞掺入（3H）胸腺嘧啶核苷的血清因子。3. 来自特异性补体抑制剂研究的补体作用证据。
Immunology. 1973 Oct;25(4):613-9.
8
The effect of plasma upon lymphocyte response in vitro. Demonstration of a humoral inhibitor in patients with sarcoidosis.血浆对体外淋巴细胞反应的影响。结节病患者体液抑制剂的证明。
Clin Exp Immunol. 1974 Dec;18(4):519-28.
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Reduced lymphocyte transformation due to a plasma factor in patients with active syphilis.活动性梅毒患者血浆因子导致淋巴细胞转化降低。
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10
Lymphocyte transformation in multiple sclerosis. Inhibition of unstimulated thymidine uptake by a serum factor.多发性硬化症中的淋巴细胞转化。血清因子对未刺激的胸腺嘧啶核苷摄取的抑制作用。
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梅毒螺旋体感染兔的体外细胞反应。II. 梅毒螺旋体感染兔血清对淋巴细胞对植物血凝素反应的抑制作用。

In vitro cell response of Treponema pallidum-infected rabbits. II. Inhibition of lymphocyte response to phytohaemagglutinin by serum of T. pallidum-infected rabbits.

作者信息

Wicher V, Wicher K

出版信息

Clin Exp Immunol. 1977 Sep;29(3):487-95.

PMID:589866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541068/
Abstract

Serum inhibitors of lymphocyte response to PHA were found in T. pallidum-infected rabbits. The humoral inhibitors could be detected as early as 10 days after infection and persisted for at least 6 months. The factors also suppressed the allogeneic lymphocyte response. Control, or normal, rabbit sera likewise contain serum inhibitors, but in much lower concentration. The detection of the humoral inhibitors depended on the susceptibility of the indicator lymphocytes. Cells of some rabbits were more sensitive to the inhibitors than others. In addition to serum inhibitors, lymphocytes of T. pallidum-infected animals seem to be impaired and responded to PHA less vigorously than cells of normal rabbits. The inhibitory activity is most likely the result of a complex group of substances with different physicochemical characteristics; some pre-exist and others are newly formed after infection. Problems associated with the detection of such inhibitors are discussed.

摘要

在感染梅毒螺旋体的兔子中发现了血清中抑制淋巴细胞对PHA反应的物质。体液抑制剂在感染后10天即可检测到，并持续至少6个月。这些因子也抑制同种异体淋巴细胞反应。对照兔或正常兔血清中同样含有血清抑制剂，但浓度要低得多。体液抑制剂的检测取决于指示淋巴细胞的敏感性。一些兔子的细胞对抑制剂比其他兔子的细胞更敏感。除血清抑制剂外，感染梅毒螺旋体动物的淋巴细胞似乎受损，对PHA的反应不如正常兔子的细胞强烈。抑制活性很可能是一组具有不同物理化学特性的物质共同作用的结果；有些物质在感染前就已存在，而其他物质则是感染后新形成的。文中讨论了与检测此类抑制剂相关的问题。