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9L大鼠脑多细胞肿瘤球体中的葡萄糖分布及其对细胞坏死的影响。

The glucose distribution in 9L rat brain multicell tumor spheroids and its effect on cell necrosis.

作者信息

Li C K

出版信息

Cancer. 1982 Nov 15;50(10):2066-73. doi: 10.1002/1097-0142(19821115)50:10<2066::aid-cncr2820501017>3.0.co;2-x.

DOI:10.1002/1097-0142(19821115)50:10<2066::aid-cncr2820501017>3.0.co;2-x
PMID:7127250
Abstract

The glucose consumption rate of 9L rat brain tumor cells was determined as a function of concentration. Glucose uptake followed Michaelis-Menten kinetics with a Km of 0.58 mM and a Vmax of 1.6 pg/cell-min. The glucose diffusion coefficient in spheroids of 9L tumor cells was determined to be 1.5 x 10(-6) cm2/s at 37 degrees C. Using these parametric values, the glucose distribution in 9L multicell spheroids was calculated and related to the viable and necrotic zones.

摘要

测定了9L大鼠脑肿瘤细胞的葡萄糖消耗速率与浓度的函数关系。葡萄糖摄取遵循米氏动力学，Km为0.58 mM，Vmax为1.6 pg/细胞·分钟。在37℃下，测定9L肿瘤细胞球体中葡萄糖的扩散系数为1.5×10⁻⁶ cm²/s。利用这些参数值，计算了9L多细胞球体中的葡萄糖分布，并将其与活区和坏死区相关联。

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