Abraham M, Kieselstein M, Hilge V, Lison S
Cell Tissue Res. 1982;225(3):567-79. doi: 10.1007/BF00214805.
Extravascular circulation in the pituitary of Mugil cephalus was investigated by injecting live fish with horseradish peroxidase and studying the distribution of the enzyme in the gland. The principal components of the extravascular circulatory system are the pericapillary spaces, and, arising from them, the interlobular and circumhypophyseal spaces. Extensions of these spaces penetrate the glandular parenchyma of the pars distalis, where they merge with pericellular spaces. In the neurohypophysis, pericapillary spaces are connected to the periaxonal spaces. Capillaries penetrating from the proximal neurohypophysis into the pars distalis are accompanied by neurosecretory axons. These axons form a mass of tissue which is limited near the capillaries by the pericapillary spaces and near the adenohypophysis by the interlobular spaces. Toward the interior of the adenohypophysis the amount of nervous tissue accompanying the capillaries progressively diminishes, thus reducing the distance between pericapillary and interlobular spaces. Within the pars distalis, the neurosecretory axons accompanying the capillaries are sparse, and the secretory and stellate cells are mostly located directly adjacent to the pericapillary spaces. In the neurointermediate lobe, interlobular spaces outline the neuro-adenohypophyseal boundary. The relationship between extravascular spaces and hormone-secreting cells varies in the different regions of the adenohypophysis depending upon the type of neurosecretory innervation in the respective region. In the regions of prolactin and gonadotropin cells, where neurosecretory axons are in direct contact with the secretory cells, the hormone-secreting and stellate cells are adjacent to the pericapillary spaces. In the regions of ACTH and STH cells, secretory and stellate cells are found adjacent to the interlobular spaces, which are interposed between the cells and the neurosecretory axons.
通过给活的鲻鱼注射辣根过氧化物酶并研究该酶在腺体内的分布，对鲻鱼垂体的血管外循环进行了研究。血管外循环系统的主要组成部分是毛细血管周围间隙，以及由它们产生的小叶间间隙和垂体周围间隙。这些间隙的延伸穿透远侧部的腺实质，并在那里与细胞周间隙融合。在神经垂体中，毛细血管周围间隙与轴突周间隙相连。从神经垂体近端穿入远侧部的毛细血管伴有神经分泌轴突。这些轴突形成一团组织，在毛细血管附近被毛细血管周围间隙限制，在腺垂体附近被小叶间间隙限制。朝着腺垂体内部，伴随毛细血管的神经组织数量逐渐减少，从而缩短了毛细血管周围间隙和小叶间间隙之间的距离。在远侧部内，伴随毛细血管的神经分泌轴突稀疏，分泌细胞和星状细胞大多直接位于毛细血管周围间隙附近。在神经中间叶，小叶间间隙勾勒出神经腺垂体边界。血管外间隙与激素分泌细胞之间的关系在腺垂体的不同区域有所不同，这取决于各个区域的神经分泌神经支配类型。在催乳素细胞和促性腺激素细胞区域，神经分泌轴突与分泌细胞直接接触，激素分泌细胞和星状细胞与毛细血管周围间隙相邻。在促肾上腺皮质激素细胞和生长激素细胞区域，分泌细胞和星状细胞位于小叶间间隙附近，小叶间间隙介于细胞和神经分泌轴突之间。
