Brohee D, Kennes B, Neve P
Clin Exp Immunol. 1982 Aug;49(2):474-80.
When put into 37 degrees C incubation, the E rosettes dissociate spontaneously and the sheep erythrocytes (SRBC) form caps at one pole of the lymphocytes. This process is associated with changes in cell morphology such as uropod formation or membrane budding. The disintegration of E rosettes and the capping of SRBC can be retarded by addition of cytochalasin B plus colchicine, chlorpromazine or sodium azide. These findings suggest a pivotal role of the cytoskeleton in the dissociation process of E rosettes. However, other mechanisms of disintegration are to be considered since none of the drugs can prevent the dissociation of E rosette entirely.
将其置于37℃孵育时，E花环会自发解离，绵羊红细胞（SRBC）在淋巴细胞的一极形成帽状物。此过程与细胞形态变化有关，如尾足形成或膜出芽。加入细胞松弛素B加秋水仙碱、氯丙嗪或叠氮化钠可延缓E花环的解体和SRBC的帽化。这些发现表明细胞骨架在E花环的解离过程中起关键作用。然而，由于没有一种药物能完全阻止E花环的解离，因此还应考虑其他解体机制。
