动脉血pH值和HCO₃⁻浓度对离体血液灌注犬胰腺HCO₃⁻分泌的影响。

Effects of arterial pH and HCO-3 concentration on HCO-3 secretion in the isolated blood-perfused dog pancreas.

作者信息

Iijima F, Yamagishi F, Iwatsuki K, Chiba S

出版信息

Arch Int Pharmacodyn Ther. 1986 Feb;279(2):314-23.

Abstract

We examined the effects of plasma pH and plasma HCO-3 concentration on pancreatic HCO-3 secretion in resting state and in stimulated state by secretin, pancreozymin or dopamine, using the isolated blood-perfused dog pancreas. Secretin- or pancreozymin-induced HCO-3 secretion was sensitive to changes in both plasma pH and HCO-3 concentration. On the other hand, neither plasma pH nor plasma HCO-3 concentration affected dopamine-induced HCO-3 secretion and spontaneous HCO-3 secretion. These results suggest that secretin- or pancreozymin-induced pancreatic HCO-3 secretion is induced by the active H+-pump, but dopamine-induced or spontaneous pancreatic HCO-3 secretion may be caused by different mechanisms.

摘要

我们使用离体血液灌注的犬胰腺，研究了血浆pH值和血浆HCO₃⁻浓度在静息状态以及由促胰液素、促胰酶素或多巴胺刺激状态下对胰腺HCO₃⁻分泌的影响。促胰液素或促胰酶素诱导的HCO₃⁻分泌对血浆pH值和HCO₃⁻浓度的变化均敏感。另一方面，血浆pH值和血浆HCO₃⁻浓度均不影响多巴胺诱导的HCO₃⁻分泌和自发性HCO₃⁻分泌。这些结果表明，促胰液素或促胰酶素诱导的胰腺HCO₃⁻分泌是由活性H⁺泵介导的，但多巴胺诱导的或自发性胰腺HCO₃⁻分泌可能由不同机制引起。