Iwatsuki K, Yamagishi F, Homma N, Haruta K, Chiba S
Arch Int Pharmacodyn Ther. 1986 Mar;280(1):145-52.
The effects of verapamil on the dopamine-induced pancreatic exocrine secretion were investigated in the isolated and blood-perfused canine pancreas at a constant flow rate in situ. All drugs were given intra-arterially. Dose-related increases in the volume of pancreatic secretion induced by dopamine (1-10 micrograms) were reduced by infusion of 50 and 100 micrograms/min of verapamil, but were not affected by diltiazem (100 micrograms/min) and dilazep (100 micrograms/min) infusions. Protein concentration in pancreatic juice induced by dopamine was decreased significantly by the infusion of verapamil, diltiazem and dilazep, but bicarbonate concentration was not. These results suggest that verapamil reduced the dopamine-induced pancreatic secretion by virtue of its dopamine antagonist activity and inhibited protein secretion by virtue of its calcium channel blocking action.
在原位以恒定流速对离体且有血液灌注的犬胰腺进行研究，观察维拉帕米对多巴胺诱导的胰腺外分泌的影响。所有药物均通过动脉内给药。多巴胺（1 - 10微克）诱导的胰腺分泌量呈剂量相关性增加，输注50和100微克/分钟的维拉帕米可使其减少，但地尔硫䓬（100微克/分钟）和双嘧达莫（100微克/分钟）输注对此无影响。多巴胺诱导的胰液中蛋白质浓度在输注维拉帕米、地尔硫䓬和双嘧达莫后显著降低，但碳酸氢盐浓度未受影响。这些结果表明，维拉帕米凭借其多巴胺拮抗活性降低了多巴胺诱导的胰腺分泌，并凭借其钙通道阻滞作用抑制了蛋白质分泌。
