通过抗体检测和强毒病毒攻击测定两种猫用狂犬病疫苗的效力。

Potency of two rabies vaccines in cats as determined by antibody assay and virulent virus challenge.

作者信息

Kihm U, Lazarowicz M, Bommeli W, Zutter R

出版信息

Comp Immunol Microbiol Infect Dis. 1982;5(1-3):227-32. doi: 10.1016/0147-9571(82)90042-x.

Abstract

The persistence of immunity induced by a modified live virus rabies vaccine (SAD strain) and an inactivated rabies vaccine combined with panleukopenia vaccine in cats was studied serologically and by virulent rabies virus challenge. The source of challenge virus was a suspension of a dog salivary gland. All 16 cats vaccinated with the inactivated vaccine developed high antibody titres and 15 were protected against the virus challenge. All 8 cats vaccinated with the MLV vaccine produced a serological immune response but 5 cats were not protected against the virus challenge. Some reasons for this phenomenon are discussed.

摘要

通过血清学检测以及用强毒狂犬病病毒攻击，研究了猫用改良活病毒狂犬病疫苗（SAD株）和灭活狂犬病疫苗联合细小病毒疫苗诱导的免疫持久性。攻击病毒的来源是犬唾液腺悬液。所有16只接种灭活疫苗的猫均产生了高抗体滴度，其中15只对病毒攻击具有抵抗力。所有8只接种MLV疫苗的猫都产生了血清学免疫反应，但有5只猫对病毒攻击没有抵抗力。文中讨论了这种现象的一些原因。