Gross V, Flemming B, Roloff D, Birkhahn H J
Dtsch Z Verdau Stoffwechselkr. 1982;42(4):169-76.
The transport of sodium ions and glucose is a specialized membrane function. Variations in the cholesterol content of the cell membrane influence these functions. The influence of a hypercholesterolemia upon the intracellular sodium concentration and the glucose tolerance was investigated in cholesterol/rape oil and in cholesterol fed rabbits. The cholesterol/rape oil fed rabbits had lower KG-values and higher peripheral insulin levels than the control animals. The Na+Ery was decreased after 12 weeks of hypercholesterolemia. The na+Muscle was not changed. A negative correlation was found between the KG-value and the Na+Ery (Na+Muscle) in normal rabbits. In the hypercholesterolemic rabbits existed a negative correlation between the KG-value and the Na+Muscle and a positive correlation between the KG-value and the Na+Ery. It was postulated that membrane functions determined these correlations.
钠离子和葡萄糖的转运是一种特殊的膜功能。细胞膜胆固醇含量的变化会影响这些功能。在喂食胆固醇/菜籽油和胆固醇的兔子中，研究了高胆固醇血症对细胞内钠浓度和葡萄糖耐量的影响。喂食胆固醇/菜籽油的兔子比对照动物的KG值更低，外周胰岛素水平更高。高胆固醇血症12周后，红细胞钠含量降低。肌肉钠含量没有变化。正常兔子的KG值与红细胞钠含量（肌肉钠含量）之间存在负相关。在高胆固醇血症兔子中，KG值与肌肉钠含量之间存在负相关，而KG值与红细胞钠含量之间存在正相关。据推测，膜功能决定了这些相关性。
