Gross V, Flemming B, Roloff D
Z Gesamte Inn Med. 1985 Apr 1;40(7):193-8.
In rabbits with standard diet, in cholesterolaemic rabbits, in pregnant women with physiological hyperinsulinism and in a control group with lower peripheral insulin concentrations after glucose load negative correlations were found between the intracellular sodium content and the KG-value of the intravenous glucose tolerance test. The hormonally regulated blood glucose regulating circle was a prerequisite for these relations, since in vitro a high sodium concentration in the erythrocytes was connected with a high glucose uptake rate. The findings in the total organism were explained by cell membrane properties which stabilise the level of the intracellular sodium concentration as well as are important for functions of the blood glucose regulating circle. As a link between the carbohydrate metabolism and the electrolyte metabolism the SH-groups of the cell membrane were discussed. This concept was used for a pathophysiological explanation of the higher erythrocytic sodium concentrations proved in manifest diabetics.
在食用标准饮食的兔子、患有高胆固醇血症的兔子、患有生理性高胰岛素血症的孕妇以及葡萄糖负荷后外周胰岛素浓度较低的对照组中，发现静脉葡萄糖耐量试验的细胞内钠含量与KG值之间呈负相关。激素调节的血糖调节循环是这些关系的前提条件，因为在体外，红细胞中高钠浓度与高葡萄糖摄取率相关。整个生物体中的这些发现可以通过细胞膜特性来解释，这些特性既能稳定细胞内钠浓度水平，又对血糖调节循环的功能很重要。细胞膜的SH基团作为碳水化合物代谢和电解质代谢之间的联系进行了讨论。这一概念被用于对显性糖尿病患者中红细胞钠浓度较高进行病理生理学解释。
