Jones R B, Ardery B R, Hui S L, Cleary R E
Fertil Steril. 1982 Nov;38(5):553-8. doi: 10.1016/s0015-0282(16)46634-3.
Although salpingitis frequently produces tubal damage and infertility, many women with tubal factor as a cause of their infertility do not have a clinical history of salpingitis. In order to investigate whether or not some such cases might be due to subclinical chlamydial infections, we measured antichlamydial antibodies in the serum of 172 women consecutively undergoing evaluation for infertility. Only 16 (9.3%) had a prior history of salpingitis. Sixty-one (35%) had antichlamydial antibodies (S+), and of these 75% had tubal factor as a sole or contributing cause of their infertility, versus 28% of the seronegative (S-) women (x2 - 34, P less than 0.001). There was no association between chlamydial seropositivity and any infertility factor other than tubal factor in multivariant analyses. Subclinical infections with Chlamydia trachomatitis may be a major cause of tubal infertility in the United States, and chlamydial serologic studies may be useful in identifying the subset of infertile women likely to have tubal factor.
尽管输卵管炎常导致输卵管损伤和不孕，但许多因输卵管因素导致不孕的女性并无输卵管炎的临床病史。为了研究某些此类病例是否可能归因于亚临床衣原体感染，我们对172名连续接受不孕评估的女性血清中的抗衣原体抗体进行了检测。只有16名（9.3%）有输卵管炎病史。61名（35%）有抗衣原体抗体（S+），其中75%的不孕原因是输卵管因素单独或起作用，而血清阴性（S-）女性中这一比例为28%（χ² = 34，P < 0.001）。在多变量分析中，衣原体血清阳性与除输卵管因素外的任何不孕因素均无关联。沙眼衣原体的亚临床感染可能是美国输卵管性不孕的主要原因，衣原体血清学研究可能有助于识别可能存在输卵管因素的不孕女性亚组。
