Matsuzawa A, Kaneko T, Ikeda Y, Yamamoto T
Gan. 1982 Jun;73(3):372-6.
TPDMT-4 tumors showed significant growth in pregnant mice but not in virgins. Tumor pieces at transplant generation 14 were implanted into the gland-free (right) and the intact (left) fat pads in virgin mice and followed over a one-year period. The transplants formed outgrowths similar to normal mammary glands in the cleared fat pads. The outgrowths were hyperactive when compared with host glands and varied from one mouse to another in extent of development. In contrast, they did not outgrow and remained as traces among host glands in the intact fat pads. Tumors developed 41 and 32 weeks after implantation in the right and the left fat pads, respectively, in one of 18 mice. The tumor from the cleared fat pad was an ovarian-sensitive pale cell carcinoma, and contained estrogen receptors (ER) but not progesterone receptors (PR). That from the intact fat pad was a type B carcinoma which was ovarian-dependent and contained both ER and PR at levels comparable to those of the parent tumor.
TPDMT - 4肿瘤在怀孕小鼠中显著生长，但在未孕小鼠中则不然。将传代14代的肿瘤组织块植入未孕小鼠的无腺体（右侧）和完整（左侧）脂肪垫中，并随访一年。移植组织在清除后的脂肪垫中形成了类似于正常乳腺的增生组织。与宿主腺体相比，这些增生组织活性过高，且在不同小鼠之间的发育程度有所差异。相比之下，它们在完整脂肪垫的宿主腺体中没有生长，仅留下痕迹。在18只小鼠中的1只小鼠里，分别在右侧和左侧脂肪垫植入肿瘤组织后41周和32周出现了肿瘤。来自清除后脂肪垫的肿瘤是一种对卵巢敏感的淡色细胞癌，含有雌激素受体（ER）但不含有孕激素受体（PR）。来自完整脂肪垫的肿瘤是B型癌，依赖卵巢，且ER和PR水平与原发肿瘤相当。
