第三类新型肿瘤启动子，即聚乙酸酯类（脱溴海兔毒素和海兔毒素），能够区分与肿瘤启动子相关的生物学作用。
The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters.
作者信息
Fujiki H, Suganuma M, Nakayasu M, Hoshino H, Moore R E, Sugimura T
出版信息
Gan. 1982 Jun;73(3):495-7.
PMID:7129014
Abstract
Aplysiatoxin is a new class of potent tumor promoter and debromoaplysiatoxin may be a weak promoter. Aplysiatoxin and debromoaplysiatoxin showed the same potency on irritation of mouse ear and induction of ornithine decarboxylase activity on mouse skin, but debromoaplysiatoxin was much weaker than aplysiatoxin in induction of adhesion of HL-60 cells.
摘要
海兔毒素是一类新型强效肿瘤促进剂，而脱溴海兔毒素可能是一种弱促进剂。海兔毒素和脱溴海兔毒素在刺激小鼠耳部以及诱导小鼠皮肤鸟氨酸脱羧酶活性方面表现出相同的效力，但在诱导HL-60细胞黏附方面，脱溴海兔毒素比海兔毒素弱得多。
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