Chamla Y, Bégueret J
Hum Genet. 1982;61(1):73-5. doi: 10.1007/BF00291339.
Colchicine-resistant human cells were initially observed in patients exhibiting C-anaphases or tetraploidy in lymphocyte cultures. Cell lines established from these patients displayed cross-resistances to daunomycin, emetine, vinblastine, and vincristine and collateral sensitivity to Xylocaine, showing a pleiotropic phenotype similar to that described in permeability mutants in CHO cells. 3H colchicine uptake and binding assays confirmed a decreased permeability to the drug.
在淋巴细胞培养中表现出C后期或四倍体的患者中最初观察到对秋水仙碱耐药的人类细胞。从这些患者建立的细胞系对柔红霉素、依米丁、长春碱和长春新碱表现出交叉耐药性，对利多卡因表现出并行敏感性，呈现出与CHO细胞通透性突变体中描述的多效性表型相似的表型。3H秋水仙碱摄取和结合试验证实了对该药物的通透性降低。
