Dell'Orco R T, Anderson L E, Whittle W L
In Vitro. 1982 Aug;18(8):703-7. doi: 10.1007/BF02796425.
The effect of low dose UV irradiation on the reinitiation of proliferative activity and on the life span of human diploid fibroblast-like cells is described. Cells were exposed to UV at confluence or after maintenance in an arrested state. Cell division was stimulated immediately after UV irradiation or after an additional post-UV incubation period. Arrested populations of all in vitro ages exhibited a greater sensitivity to UV and the reinitiation of proliferation was enhanced by post-UV incubation before stimulation. Ultraviolet light had no effect on life span regardless of in vitro cell age, culture state at the time of exposure, or the presence of a postirradiation period of arrest.
本文描述了低剂量紫外线照射对人二倍体成纤维样细胞增殖活性再启动及寿命的影响。细胞在汇合时或处于停滞状态维持后接受紫外线照射。紫外线照射后或额外的紫外线照射后孵育期后立即刺激细胞分裂。所有体外培养龄期的停滞细胞群体对紫外线表现出更高的敏感性，并且在刺激前通过紫外线照射后的孵育可增强增殖的再启动。无论体外细胞龄期、照射时的培养状态或照射后停滞期的存在如何，紫外线对细胞寿命均无影响。
