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新生儿与健康成年人外周血玻璃黏附细胞对镉微晶的吞噬作用比较

Comparative phagocytosis of cadmium microcrystals by peripheral blood glass-adherent cells of newborn and healthy adults.

作者信息

Miler I, Vondrácek J, Machuldová I

出版信息

Immunobiology. 1982 Aug;162(3):297-306. doi: 10.1016/S0171-2985(11)80009-4.

DOI:10.1016/S0171-2985(11)80009-4
PMID:7129524
Abstract

Microcrystals of cadmium, saturated with human serum albumin, were employed as a microassay for phagocytosis by glass-adherent blood cells. Using this assay, it was found that leukocytes of newborns possess significantly higher phagocytic activity and that a higher proportion of active phagocytic cells is present in newborns than in adults. In contrast, adult sera contain higher level of opsonins for cadmium microcrystals than cord sera. Heat inactivation and zymosan absorption of both adult and cord sera decreased significantly the opsonic power of sera, thus suggesting the participation of complement in opsonization of these particles.

摘要

用人血清白蛋白饱和的镉微晶作为玻璃黏附血细胞吞噬作用的微量测定法。使用该测定法发现,新生儿的白细胞具有明显更高的吞噬活性,并且新生儿中具有活性吞噬细胞的比例高于成年人。相比之下,成人血清中针对镉微晶的调理素水平高于脐带血清。成人血清和脐带血清的热灭活及酵母聚糖吸收均显著降低了血清的调理能力,因此表明补体参与了这些颗粒的调理作用。

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