正常婴儿及患ABO溶血病婴儿的单核白细胞对IgG抗A致敏红细胞的破坏作用
Destruction of IgG anti-A sensitized erythrocytes by mononuclear leucocytes from normal and ABO haemolytic disease affected infants.
作者信息
Romano E L, Rossi Devivo M L, Soyano A, Linares J
出版信息
Clin Exp Immunol. 1984 Feb;55(2):451-8.
Studies were undertaken to investigate the antibody-dependent cell-mediated cytotoxicity (ADCC) activity of mononuclear leucocytes (MNL) from cord and healthy adult blood and that from infants with ABO haemolytic disease. The ADCC levels of MNL from both types of newborn blood were found to be higher than that of MNL from adult blood. The extent of ADCC was positively related to the degree of antibody sensitization of the red cells and to the effector cell target cell ratio. The ADCC activity was effected mainly by the adherent cell fraction and could be inhibited by cytochalasin B, hydrocortisone and also by high concentrations (more than 0.5 mg/ml) of non-specific free human IgG. Phagocytosis was also demonstrated to be an important mechanism in the destruction of IgG anti-A coated red cells by the MNL.
开展了多项研究，以调查来自脐带血和健康成人血液以及患有ABO溶血病婴儿的单核白细胞（MNL）的抗体依赖性细胞介导的细胞毒性（ADCC）活性。发现两种新生儿血液中MNL的ADCC水平均高于成人血液中MNL的ADCC水平。ADCC的程度与红细胞抗体致敏程度以及效应细胞与靶细胞的比例呈正相关。ADCC活性主要受贴壁细胞部分影响，并且可被细胞松弛素B、氢化可的松以及高浓度（超过0.5mg/ml）的非特异性游离人IgG抑制。吞噬作用也被证明是MNL破坏IgG抗A包被红细胞的重要机制。
Zotero 插件