Hofstra W, de Vries-Hospers H G, van der Waaij D
Infection. 1982;10(4):223-7. doi: 10.1007/BF01666915.
We have investigated which dose of amphotericin B can be regarded as an optimal oral dose for the prophylaxis of colonization of the digestive tract by Candida species. Ten human volunteers were given different doses; each dose was administered for five days. The results of this study revealed that although oral doses of 0.5 g amphotericin B per day resulted in sufficient concentrations in 70% of the faecal samples obtained during application, higher doses (1.5 or 2 g per day) were required to obtain detectable amphotericin B activity in 95% and 100% of the samples, respectively. A daily dose of 1.0 g is recommended. We have taken into consideration the variation in amphotericin B concentrations among individuals following this recommended dose.
我们研究了哪种剂量的两性霉素B可被视为预防念珠菌属在消化道定植的最佳口服剂量。10名人类志愿者接受了不同剂量的药物；每个剂量给药5天。本研究结果表明，虽然每天口服0.5g两性霉素B可使70%的给药期间采集的粪便样本中达到足够的浓度，但分别需要更高的剂量（每天1.5g或2g）才能使95%和100%的样本中检测到两性霉素B活性。建议每日剂量为1.0g。我们已考虑到按照该推荐剂量给药后个体间两性霉素B浓度的差异。
