Mellor H, Parker P J
Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Biochem J. 1998 Jun 1;332 ( Pt 2)(Pt 2):281-92. doi: 10.1042/bj3320281.
Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in a multitude of cellular processes, ranging from control of fundamental cell autonomous activities, such as proliferation, to more organismal functions, such as memory. However, understanding of mammalian PKC signalling systems is complicated by the large number of family members. Significant progress has been made through studies based on comparative analysis, which have defined a number of regulatory elements in PKCs which confer specific location and activation signals to each isotype. Further studies on simple organisms have shown that PKC signalling paradigms are conserved through evolution from yeast to humans, underscoring the importance of this family in cellular signalling and giving novel insights into PKC function in complex mammalian systems.
哺乳动物蛋白激酶C（PKC）超家族的成员在众多细胞过程中发挥关键调节作用，从控制基本的细胞自主活动，如增殖，到更高级的机体功能，如记忆。然而，由于家族成员众多，对哺乳动物PKC信号系统的理解变得复杂。通过基于比较分析的研究取得了重大进展，这些研究确定了PKC中的一些调节元件，这些元件赋予每种同工型特定的定位和激活信号。对简单生物体的进一步研究表明，PKC信号模式从酵母到人类在进化过程中是保守的，这突出了该家族在细胞信号传导中的重要性，并为复杂哺乳动物系统中PKC的功能提供了新的见解。
