Johnels B, Steg G
J Neurosci Methods. 1982 Jul;6(1-2):17-27. doi: 10.1016/0165-0270(82)90013-9.
A simple treadmill arrangement has been developed to quantify the quadruped or hindleg locomotor activity in rats. The method provides information on the accumulated distance passed by the rat in the treadmill but also on the temporal distribution of locomotion and the stepping cycle. It can be used with intact rats but also during stereotaxically guided electric stimulation of the brain. The accumulated locomotion produced by apomorphine showed a partly linear relation to the dose and the results were comparable to those found with other methods. The locomotor effect of brainstem stimulation was enhanced by apomorphine. This method combines the advantages of several other methods and is well suited as a tool for the analysis of nervous regulation of locomotor activity.
已经开发出一种简单的跑步机装置来量化大鼠的四足或后肢运动活动。该方法不仅能提供大鼠在跑步机上走过的累计距离信息，还能提供运动的时间分布和步周期信息。它既可以用于完整的大鼠，也可以在立体定位引导的脑电刺激过程中使用。阿扑吗啡产生的累计运动与剂量呈部分线性关系，结果与其他方法所得结果相当。阿扑吗啡增强了脑干刺激的运动效应。这种方法结合了其他几种方法的优点，非常适合作为分析运动活动神经调节的工具。
