自发性高血压大鼠血小板周转率和前列腺素生成增加。
Enhanced platelet turnover and prostaglandin production in spontaneously hypertensive rats.
作者信息
De Clerck F, Van Gorp L, Xhonneux B, Somers Y, Wouters L
出版信息
Thromb Res. 1982 Aug 1;27(3):243-9. doi: 10.1016/0049-3848(82)90071-8.
PMID:7135358
Abstract
The anti-hypertensive effect of ketanserin, a selective 5-HT2 antagonist, both in experimental and human pathology (1,2) could implicate the blood platelets as a source for peripherally available 5-hydroxytryptamine (5-HT), acting to increase peripheral vascular resistance (3). Therefore we examined various blood platelet parameters in spontaneously hypertensive rats in comparison with normotensive Wistar rats.
摘要
酮色林是一种选择性5-羟色胺2（5-HT2）拮抗剂，其在实验性和人类病理学中均具有抗高血压作用（1,2），这可能意味着血小板是外周可利用的5-羟色胺（5-HT）的来源，该物质可增加外周血管阻力（3）。因此，我们比较了自发性高血压大鼠与正常血压的Wistar大鼠的各种血小板参数。
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