Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats.
作者信息
Jensen D R, Tone J N, Sorensen R H, Bozek S A
出版信息
Toxicology. 1982;24(1):65-72. doi: 10.1016/0300-483x(82)90063-4.
PMID:7135404
Abstract
Male rats received daily, oral doses of gossypol-acetate (40 mg/kg body wt) for 2, 4, or 8 weeks to determine patterns of gossypol deposition in the spleen, liver, heart, kidneys, lungs, and testes during establishment of a gossypol-induced infertility. Infertility was exhibited at the end of the 4-week dosing period. Free and bound gossypol accumulated in all of the organs.
摘要
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