Goldstein F, Khoury J, Thornton J J
Am J Gastroenterol. 1976 Mar;65(3):201-8.
Four patients with severe chronic radiation enteritis and/or colitis were treated with anti-inflammatory drugs that are used conventionally in the treatment of idiopathic inflammatory bowel disease. Salicylazosulfapyridine (SASP) was used in the treatment of all four patients, while one patient received oral prednisone together with SASP. All four patients were treated and observed for over one year, with follow-up observations now extending to over three years. The four patients showed striking clinical improvement, accompanied by improvement in the radiographic appearance of affected bowel, complete or almost complete in three and incomplete in the fourth patient. The results of this pilot investigation are encouraging and call for wider clinical trials of the same and related drugs in larger groups of patients with chronic radiation enterocolitis, a serious condition that has until now not been successfully treated with drugs.
四名患有严重慢性放射性肠炎和/或结肠炎的患者接受了用于特发性炎症性肠病常规治疗的抗炎药物治疗。所有四名患者均使用柳氮磺胺吡啶（SASP）进行治疗，其中一名患者在使用SASP的同时还口服了泼尼松。所有四名患者均接受了一年以上的治疗和观察，目前随访观察已延长至三年以上。这四名患者的临床症状有显著改善，同时受累肠道的影像学表现也有所改善，三名患者完全或几乎完全改善，第四名患者改善不完全。这项初步研究的结果令人鼓舞，呼吁对更大组的慢性放射性小肠结肠炎患者进行相同及相关药物的更广泛临床试验，这种严重疾病迄今为止尚未通过药物得到成功治疗。
