Muir A, Howe-Davies S A, Turner R C
Am J Med. 1982 Nov;73(5):637-40. doi: 10.1016/0002-9343(82)90403-x.
Non-insulin-dependent diabetes can be treated using two criteria, the fasting blood glucose concentration and body weight. The feasibility of this means of control, aiming for a fasting blood glucose concentration of less than 6 mmol/liter (108 mg/dl) has been investigated in 10 general practices. Eight practices now use the method routinely. A one-year follow-up in six practices is reported. The number of patients with a fasting blood glucose concentration of less than 108 mg/dl increased from 39 (26 percent) to 65 (59 percent). The mean fasting blood glucose concentration of all 112 patients was significantly (p less than 0.01) decreased from a mean of 148 to 113 mg/dl at three months, and subsequently increased to a still reduced (p less than 0.01) level of 126 mg/dl after one year. The mean hemoglobin A1c level was decreased (p less than 0.01). Six practices preferred to have special clinics at which fasting blood glucose meaurements were taken. Two practices achieved good results with the administration and tests being undertaken by a practical nurse, with supervision from the general practitioner. Assessment of control by four fasting blood glucose determinations a year is less expensive than regular urine tests, and may improve blood glucose control.
非胰岛素依赖型糖尿病可根据空腹血糖浓度和体重这两个标准进行治疗。在10家普通诊所对以空腹血糖浓度低于6毫摩尔/升(108毫克/分升)为目标的这种控制方法的可行性进行了研究。现在有8家诊所常规使用该方法。报告了对6家诊所的一年随访情况。空腹血糖浓度低于108毫克/分升的患者人数从39名(26%)增至65名(59%)。所有112名患者的平均空腹血糖浓度在三个月时从平均148毫克/分显著降至113毫克/分(p<0.01),随后在一年后升至仍较低(p<0.01)的126毫克/分水平。糖化血红蛋白A1c的平均水平降低(p<0.01)。6家诊所倾向于设立进行空腹血糖测量的专门诊所。两家诊所由一名实习护士在全科医生的监督下进行管理和检测,取得了良好效果。每年通过四次空腹血糖测定来评估控制情况比定期尿检成本更低,并且可能改善血糖控制。