Davies J, Gibson D G, Foale R, Heer K, Spry C J, Oakley C M, Goodwin J F
Br Heart J. 1982 Nov;48(5):434-40. doi: 10.1136/hrt.48.5.434.
Nine patients with eosinophilic endomyocardial disease who had undergone angiocardiography with histological staging of their disease, were studied by M-mode and two dimensional echocardiography to determine the extent to which specific features of the disease could be evaluated by these non-invasive methods. In seven patients, amplitude processed two dimensional echocardiography showed regions where the relative intensity of endomyocardial echoes was greater than normal, and their distribution corresponded to known areas of fibrosis. Standard two dimensional echocardiography was normal in all but three patients. In eight patients M-mode echocardiography showed only non-specific abnormalities, but appeared to be useful in assessing the functional consequences of myocardial or mitral valve disease. After digitisation a reduction in the duration and an increase in the peak rate of dimension increase during filling was prolonged. It was concluded that amplitude processed two dimensional echocardiography might be useful in diagnosing the extent and severity of endomyocardial disease in patients with hyperosinophilia. These noninvasive techniques may thus provide a means for the early diagnosis of endomyocardial fibrosis and could be useful in assessing in progression or response to treatment.
对9例患有嗜酸性粒细胞性心内膜疾病且已接受心血管造影及疾病组织学分期的患者，采用M型和二维超声心动图进行研究，以确定这些非侵入性方法能够评估该疾病特定特征的程度。在7例患者中，振幅处理二维超声心动图显示心内膜回声相对强度高于正常的区域，其分布与已知的纤维化区域相符。除3例患者外，所有患者的标准二维超声心动图均正常。在8例患者中，M型超声心动图仅显示非特异性异常，但似乎有助于评估心肌或二尖瓣疾病的功能后果。数字化处理后，充盈期维度增加的持续时间缩短，峰值速率增加。得出的结论是，振幅处理二维超声心动图可能有助于诊断高嗜酸性粒细胞血症患者心内膜疾病的范围和严重程度。因此，这些非侵入性技术可能为心内膜纤维化的早期诊断提供一种方法，并且在评估疾病进展或治疗反应方面可能有用。
