Shaw T R, Logan-Sinclair R B, Surin C, McAnulty R J, Heard B, Laurent G J, Gibson D G
Br Heart J. 1984 Jan;51(1):46-53. doi: 10.1136/hrt.51.1.46.
Cross sectional echocardiograms were recorded within one week of death in seven patients with valvular heart disease, four with coronary artery disease, and nine with congenital heart disease. Regional echo amplitude was measured from the cross sectional display by constructing histograms of pixel intensity. Parietal pericardium was used as an internal standard for setting the gain of the instrument. At necropsy myocardium was taken from the free wall of the left ventricle, the papillary muscles, and the septum. Fibrosis was assessed histologically and biochemically as hydroxyproline content. In individual samples histological and biochemical estimates were correlated. In all regions other than the septum in patients with left ventricular hypertrophy, log [collagen] correlated with median pixel intensity. The amplitude of reflected echoes from the hypertrophied septum was significantly higher than that from other samples but was similarly correlated with collagen content. Agreement between echo amplitude and histological grade was significantly less good. Thus in chronic left ventricular disease myocardial collagen content appears to be the major determinant of regional echo intensity. Reproducibility of measurements and more rigorous definition of tissue abnormalities will, however, require further study.
对7例瓣膜性心脏病、4例冠状动脉疾病和9例先天性心脏病患者在死亡后一周内进行了横断面超声心动图检查。通过构建像素强度直方图，从横断面显示中测量局部回声幅度。以壁层心包作为设定仪器增益的内部标准。尸检时，从左心室游离壁、乳头肌和室间隔取材心肌。通过组织学和生化方法评估纤维化程度，以羟脯氨酸含量表示。对单个样本的组织学和生化评估进行相关性分析。在左心室肥厚患者的除室间隔外的所有区域，对数[胶原]与像素强度中位数相关。肥厚室间隔的反射回声幅度明显高于其他样本，但与胶原含量的相关性相似。回声幅度与组织学分级之间的一致性明显较差。因此，在慢性左心室疾病中，心肌胶原含量似乎是局部回声强度的主要决定因素。然而，测量的可重复性和组织异常的更严格定义需要进一步研究。
