人类肿瘤对分次放疗的不同反应可能归因于照射后的修复过程。
The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.
作者信息
Weichselbaum R R, Little J B
出版信息
Br J Cancer. 1982 Oct;46(4):532-7. doi: 10.1038/bjc.1982.237.
Abstract
We have measured post-irradiation recovery (potentially lethal damage repair) after fractionated radiation in plateau-phase cultures of two human tumour cell lines derived from tumours of different radiocurabilities (melanoma and breast). Although the radiation survival-curve parameters of these cell lines are similar, the repair of potentially lethal X-ray damage after fractionated X-ray treatment conferred significant radioresistance on the human melanoma cells but not the human breast carcinoma cells. We suggest that the repair of potentially lethal damage may correlate with clinical radiocurability.
摘要
我们已经测量了源自不同放射敏感性肿瘤（黑色素瘤和乳腺癌）的两个人类肿瘤细胞系在平台期培养物中分次照射后的辐射后恢复（潜在致死性损伤修复）情况。尽管这些细胞系的辐射存活曲线参数相似，但分次X射线治疗后潜在致死性X射线损伤的修复赋予了人类黑色素瘤细胞显著的放射抗性，而人类乳腺癌细胞则没有。我们认为潜在致死性损伤的修复可能与临床放射敏感性相关。
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本文引用的文献
1
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Nature. 1959 Oct 24;184:1293-5. doi: 10.1038/1841293a0.
2
The histological structure of some human lung cancers and the possible implications for radiotherapy.一些人类肺癌的组织学结构及其对放射治疗的可能影响。
Br J Cancer. 1955 Dec;9(4):539-49. doi: 10.1038/bjc.1955.55.
3
Cellular repair factors influencing radiocurability of human malignant tumours.影响人类恶性肿瘤放射可治愈性的细胞修复因子
Br J Cancer. 1982 Jan;45(1):10-6. doi: 10.1038/bjc.1982.2.
4
Analysis of tumour responses by excision and in vitro assay of cellular clonogenic capacity.通过切除肿瘤并进行细胞克隆形成能力的体外测定来分析肿瘤反应。
Br J Cancer Suppl. 1980 Apr;4:209-16.
5
X-ray sensitivity of human tumor cells in vitro.人肿瘤细胞在体外的X射线敏感性
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6
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7
Radiobiology's contribution to radiotherapy: promise or mirage? Failla Memoral Lecture.
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