Szilárd S, Szentgyörgyi D, Bencsáth M
Morphol Igazsagugyi Orv Sz. 1978 Apr;18(2):117-24.
Authors in 1968 performing the periodoc observation of persons, working in toluene-containing athmosphera noticed the presence of hepatomegaly. Laboratory tests performed in 1968--1976 have revealed increase of the level of GOT. At 22 workers out of 170 liver biopsy was performed. By electron microscopy pathologic alterations in the mitochondria and in the rough-surfaced endoplasmic reticulum could be observed, -since these organella contain the two-third of the GOT of hepatocytes. It is assumed that mitochondria as sources of energy take part in the process of the oxydation of toulene, ribosomes of the rough-surfaced endoplasmic reticulum in the conjugation of benzoic-acid with glycine. Authors assume that there is a correlation between the damage of the organella and the detoxication of the toluene by hepatocytes.
1968年，研究人员对在含甲苯环境中工作的人员进行定期观察时，发现了肝肿大现象。1968年至1976年进行的实验室检测显示谷草转氨酶（GOT）水平升高。在170名工人中，对22人进行了肝脏活检。通过电子显微镜观察到线粒体和粗面内质网出现病理改变，因为这些细胞器含有肝细胞中三分之二的GOT。据推测，作为能量来源的线粒体参与甲苯的氧化过程，粗面内质网的核糖体参与苯甲酸与甘氨酸的结合过程。作者认为细胞器的损伤与肝细胞对甲苯的解毒作用之间存在关联。
