Heard B E, Dewar A
Diagn Histopathol. 1982 Jul-Sep;5(3):189-95.
In the course of studying a series of human bronchial and lung carcinomas by electron microscopy, we have come across a squamous cell (epidermoid) carcinoma containing two different kinds of small bodies that have not been described previously. One of them took the form of small round dense granules projecting from the surface of keratinizing tumour cells, which we have termed 'polypoid granules'. The other consisted of small oval dark densities associated with the outer membranes of the mitochondria of non-keratinizing tumour cells, which we have termed 'mitochondrial densities'. The composition of the bodies could not be identified by histochemical methods, but they are of interest since they have not been recorded previously, and may be concerned in some way with ectopic hormone production by the tumour.
在通过电子显微镜研究一系列人类支气管和肺癌的过程中，我们遇到了一种鳞状细胞（表皮样）癌，其中含有两种以前未被描述过的小体。其中一种呈小圆形致密颗粒状，从角化肿瘤细胞表面突出，我们将其称为“息肉样颗粒”。另一种由与非角化肿瘤细胞线粒体外膜相关的小椭圆形深色致密物组成，我们将其称为“线粒体致密物”。这些小体的组成无法通过组织化学方法确定，但它们很有趣，因为以前没有记录过，并且可能在某种程度上与肿瘤的异位激素产生有关。
