Carlile A, Edwards C
J Clin Pathol. 1986 Mar;39(3):284-92. doi: 10.1136/jcp.39.3.284.
As there is little published information on the ultrastructure of poorly differentiated squamous carcinoma of the bronchus 18 examples of this tumour were studied. On light microscopy 10 of the tumours contained foci of keratinisation or intercellular bridges and therefore fulfilled the World Health Organisation's diagnostic criteria. In eight these features were absent, but the overall appearance was sufficiently squamoid to preclude their placement in any other category. On electron microscopy many cells showed the characteristic desmosomes and tonofilament of of squamous carcinoma, but there were also areas of adenodifferentiation. The ultrastructure of both light microscopic groups was identical. In conclusion, this type of tumour is dimorphic with characteristics of adenocarcinoma and squamous carcinoma on electron microscopy. Keratinisation and bridges are not essential diagnostic criteria: the overall pattern and cellular morphology are more important.
由于关于支气管低分化鳞状细胞癌超微结构的已发表信息很少，因此对18例这种肿瘤进行了研究。在光学显微镜下，10例肿瘤含有角化灶或细胞间桥，因此符合世界卫生组织的诊断标准。在8例中没有这些特征，但总体外观足够鳞状，使其不能归为任何其他类别。在电子显微镜下，许多细胞显示出鳞状细胞癌的特征性桥粒和张力丝，但也有腺分化区域。两个光学显微镜组的超微结构相同。总之，这种类型的肿瘤是双相的，在电子显微镜下具有腺癌和鳞状细胞癌的特征。角化和桥不是必需的诊断标准：总体模式和细胞形态更重要。
