Bläker F, Altrogge H, Hellwege H H, Schliffke C, Stephan W
Dtsch Med Wochenschr. 1976 Apr 30;101(18):690-3. doi: 10.1055/s-0028-1104161.
Selection of donors to prevent HBs-antigen positive serum hepatitis has been only partially successful. For this reason the attempt was made to prevent the disease by passive immunisation with anti-HBs antibodies. A prerequisite for the systematic use of such immunisation is the determination of antibody threshold which would still provide protection. Plasma elimination of transmitted. HBs antibodies was serially measured in five children with terminal renal failure and ten normal subjects after intensive contact with HBs antibodies. Half-life values indicated marked individual variations which have to be taken into account with long-term prophylaxis. In the children they were 28.5, 25.9, 16.6, 11.7 and 7.8 days, respectively. In the healthy subjects the half-life averaged 20.3 days. The long-term programme developed by the authors appears to be suitable for revealing the value of hyperimmune-globulin anti-HBs in the prevention of HBs-antigen positive serum hepatitis.
选择供体以预防乙肝表面抗原阳性血清性肝炎仅取得了部分成功。因此，人们尝试通过用抗乙肝表面抗体进行被动免疫来预防这种疾病。系统使用这种免疫的一个前提是确定仍能提供保护的抗体阈值。在5名终末期肾衰竭儿童和10名正常受试者与乙肝表面抗体密切接触后，连续测量了所输注的乙肝表面抗体的血浆清除情况。半衰期值显示出明显的个体差异，在长期预防中必须加以考虑。在儿童中，半衰期分别为28.5天、25.9天、16.6天、11.7天和7.8天。在健康受试者中，半衰期平均为20.3天。作者制定的长期方案似乎适合揭示高效价乙肝免疫球蛋白在预防乙肝表面抗原阳性血清性肝炎方面的价值。
