Oram M, Wilson K, Burnett D, Al-Dabbagh S G, Idle J R, Smith R L
Eur J Clin Pharmacol. 1982;23(2):147-50. doi: 10.1007/BF00545969.
The metabolism of methaqualone to the glucuronides of 5 C-monohydroxy metabolites and to the N-oxide has been studied in 2 groups of healthy young adults phenotyped as extensive and poor metabolisers of debrisoquine. No significant interphenotype differences were observed with respect to the excretion of any of the 6 metabolites. It is probable that the genetic regulation of the pathways leading to these metabolites is at a locus other than that which is responsible for the regulation of the oxidation of debrisoquine, guanoxan, phenacetin, phenytoin and sparteine.
在两组健康年轻成年人中研究了甲喹酮代谢生成5种C-单羟基代谢物的葡糖醛酸苷以及N-氧化物的情况，这两组成年人根据异喹胍代谢能力被表型分为快代谢型和慢代谢型。在这6种代谢物的排泄方面未观察到显著的表型间差异。导致这些代谢物生成的代谢途径的遗传调控位点可能不同于负责调控异喹胍、胍生、非那西丁、苯妥英和司巴丁氧化的位点。
