Wanwimolruk S, Patamasucon P, Lee E J
Department of Pharmacology, Prince of Songkla University, Hand-Yai, Thailand.
Br J Clin Pharmacol. 1990 Feb;29(2):244-7. doi: 10.1111/j.1365-2125.1990.tb03627.x.
Debrisoquine polymorphism has been studied extensively in Caucasian populations. The prevalence of the poor metaboliser phenotype is 3-10% in European and American Caucasian populations but appears to be very low in Asian populations. This study was carried out to determine the metabolic oxidation status in 173 Thai subjects. Phenotyping was performed using the metabolic ratio (MR) calculated as the 0-8 h urinary output of debrisoquine/0-8 h urinary output of 4-hydroxydebrisoquine after oral administration of 10 mg debrisoquine hemisulphate. Two subjects (1.2%) were phenotyped as poor metabolisers; they had MR values of 13.17 and 92.04. The incidence of the poor metaboliser phenotype of debrisoquine oxidation of 1.2% seems to be lower in the Thai population compared with that in various Caucasian populations.
去甲异喹胍多态性已在白种人群体中得到广泛研究。在欧美白种人群体中，代谢不良者表型的患病率为3%至10%，但在亚洲人群体中似乎非常低。本研究旨在确定173名泰国受试者的代谢氧化状态。使用代谢比（MR）进行表型分析，代谢比计算方法为口服10毫克半硫酸去甲异喹胍后0至8小时去甲异喹胍的尿排出量/0至8小时4-羟基去甲异喹胍的尿排出量。两名受试者（1.2%）被表型为代谢不良者；他们的MR值分别为13.17和92.04。与各种白种人群体相比，泰国人群体中去甲异喹胍氧化代谢不良者表型的发生率1.2%似乎较低。
