年龄对人体中戊巴比妥钠羟化的影响。
The effect of age on the hydroxylation of amylobarbitone sodium in man.
机构信息
St Helen's Hospital, Hastings.
出版信息
Br J Clin Pharmacol. 1974 Feb;1(1):41-3. doi: 10.1111/j.1365-2125.1974.tb00204.x.
Abstract
1 Following a single oral dose of amylobarbitone sodium it has been shown that a group of young subjects convert a higher proportion of the dose to 3'-hydroxyamylobarbitone than a group of elderly subjects. 2 Twenty-four hours after the administration of the drug, the mean plasma level of amylobarbitone in the elderly group is significantly higher than in the group of young subjects. 3 It is concluded that the rate of hydroxylation of amylobarbitone sodium decreases with age.
摘要
给一组年轻受试者单口服一剂氨基丁二酰脲钠后发现，与另一组老年受试者相比，该组年轻受试者将更高比例的剂量转化为 3'-羟基氨基丁二酰脲。
给药 24 小时后，老年组的氨基丁二酰脲平均血浆水平明显高于年轻组。
结论是，氨基丁二酰脲钠的羟化率随年龄增长而降低。
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