Mate J, Moreno-Otero R, Marron C, Martinez-Raposo A, Roldan J, Pajares J M, Perez-Cuadrado S
Int J Tissue React. 1982;4(3):227-31.
Forty-one rectal samples from 22 patients with ulcerative colitis and eight rectal samples from normal controls were studied cytologically, histologically and histochemically (LDH isoenzyme pattern). The cytological specimens from patients were classified into three groups (A, B and C) and the degree of cellular atypia was compared with the modifications of LDH isoenzymogram. The differences between the polypeptide M levels of the group A, B and C were statistically significant, as well as those between groups B and C versus the normal controls. The highest percentages of M were observed in group C and correlate with the presence of large single or double nucleoli. These results most likely represent active cellular regeneration, and further investigations are needed to elucidate whether the histochemical alterations could be useful to detect precocious malignant changes in patients with long-standing ulcerative colitis.
对22例溃疡性结肠炎患者的41份直肠样本以及正常对照者的8份直肠样本进行了细胞学、组织学和组织化学（乳酸脱氢酶同工酶谱）研究。将患者的细胞学标本分为三组（A、B和C组），并将细胞异型程度与乳酸脱氢酶同工酶谱的变化进行比较。A、B和C组之间的多肽M水平差异具有统计学意义，B组和C组与正常对照组之间的差异也具有统计学意义。C组中观察到的M百分比最高，且与大的单个或双个核仁的存在相关。这些结果很可能代表活跃的细胞再生，需要进一步研究以阐明组织化学改变是否有助于检测长期溃疡性结肠炎患者的早期恶性变化。
